Role of Cathepsins in Mycobacterium tuberculosis Survival in Human Macrophages

Cathepsins are proteolytic enzymes that function in the endocytic pathway, especially in lysosomes, where they contribute directly to pathogen killing or indirectly, by their involvement in the antigen presentation pathways. Mycobacterium tuberculosis (MTB) is a facultative intracellular pathogen th...

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Bibliographic Details
Main Authors: Pires, David, Marques, Joana, Pombo, João Palma, Carmo, Nuno, Bettencourt, Paulo, Neyrolles, Olivier, Lugo-Villarino, Geanncarlo, Anes, Elsa
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004184/