Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia

Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia

DNMT3B encodes a DNA methyltransferase implicated in aberrant epigenetic changes contributing to leukemogenesis. We tested whether DNMT3B expression, measured by NanoString nCounter assay, associates with outcome, gene- and microRNA-expression and DNA methylation profiles in 210 older (≥60 years) ad...

Full description

Bibliographic Details
Main Authors:	Niederwieser, Christian, Kohlschmidt, Jessica, Volinia, Stefano, Whitman, Susan P., Metzeler, Klaus H., Eisfeld, Ann-Kathrin, Maharry, Kati, Yan, Pearlly, Frankhouser, David, Becker, Heiko, Schwind, Sebastian, Carroll, Andrew J., Nicolet, Deedra, Mendler, Jason H., Curfman, John P., Wu, Yue-Zhong, Baer, Maria R., Powell, Bayard L., Kolitz, Jonathan E., Moore, Joseph O., Carter, Thomas H., Bundschuh, Ralf, Larson, Richard A., Stone, Richard M., Mrózek, Krzysztof, Marcucci, Guido, Bloomfield, Clara D.
Format:	Online
Language:	English
Published:	2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351165/

Similar Items

GAS6 expression identifies high-risk adult AML patients: potential implications for therapy
by: Whitman, Susan P., et al.
Published: (2013)

Enrichment-based DNA methylation analysis using next-generation sequencing: sample exclusion, estimating changes in global methylation, and the contribution of replicate lanes
by: Trimarchi, Michael P, et al.
Published: (2012)

Methods for high-throughput MethylCap-Seq data analysis
by: Rodriguez, Benjamin AT, et al.
Published: (2012)

Comparison of Insertional RNA Editing in Myxomycetes
by: Chen, Cai, et al.
Published: (2012)

Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants
by: Van Emburgh, Beth O., et al.
Published: (2011)

DNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish population
by: Mostowska, Adrianna, et al.
Published: (2013)

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
by: Liao, Jing, et al.
Published: (2015)

The ‘de novo’ DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium
by: Elliott, Ellen N, et al.
Published: (2016)

Quality Control for RNA-Seq (QuaCRS): An Integrated Quality Control Pipeline
by: Kroll, Karl W, et al.
Published: (2014)

Accuracy of DNA methylation pattern preservation by the Dnmt1 methyltransferase
by: Goyal, Rachna, et al.
Published: (2006)

The STAT3-DNMT1 connection
by: Thomas, N. Shaun B.
Published: (2012)

Targeting Leukemia Stem Cells in vivo with AntagomiR-126 Nanoparticles in Acute Myeloid Leukemia
by: Dorrance, Adrienne M., et al.
Published: (2015)

Nanochannel Electroporation as a Platform for Living Cell Interrogation in Acute Myeloid Leukemia
by: Zhao, Xi, et al.
Published: (2015)

Expression of DNMT1 and DNMT3a Are Regulated by GLI1 in Human Pancreatic Cancer
by: He, ShanShan, et al.
Published: (2011)

The de novo methylation activity of Dnmt3a is distinctly different than that of Dnmt1
by: Hsieh, Chih-Lin
Published: (2005)

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1
by: Felle, Max, et al.
Published: (2011)

Time-Qualified Patterns of Variation of PPARγ, DNMT1, and DNMT3B Expression in Pancreatic Cancer Cell Lines
by: Pazienza, Valerio, et al.
Published: (2012)

Correlations among PPARγ, DNMT1, and DNMT3B Expression Levels and Pancreatic Cancer
by: Pazienza, Valerio, et al.
Published: (2012)

Mahanine restores RASSF1A expression by down-regulating DNMT1 and DNMT3B in prostate cancer cells
by: Agarwal, Soumik, et al.
Published: (2013)

DNA METHYLATION BY DNMT1 AND DNMT3b METHYLTRANSFERASES IS DRIVEN BY THE MUC1-C ONCOPROTEIN IN HUMAN CARCINOMA CELLS
by: Rajabi, Hasan, et al.
Published: (2016)

Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells
by: Li, Zhiguang, et al.
Published: (2015)

miR-124 and miR-506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1
by: Chen, Zhiheng, et al.
Published: (2015)

Black Raspberry-Derived Anthocyanins Demethylate Tumor Suppressor Genes Through the Inhibition of DNMT1 and DNMT3B in Colon Cancer Cells
by: Wang, Li-Shu, et al.
Published: (2013)

On the Evolutionary Origin of Eukaryotic DNA Methyltransferases and Dnmt2
by: Jurkowski, Tomasz P., et al.
Published: (2011)

PKC isoforms interact with and phosphorylate DNMT1
by: Lavoie, Geneviève, et al.
Published: (2011)

Significance of DNMT3b in Oral Cancer
by: Chen, Wen-Cheng, et al.
Published: (2014)

Lsh regulates LTR retrotransposon repression independently of Dnmt3b function
by: Dunican, Donncha S, et al.
Published: (2013)

Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia
by: Jost, E, et al.
Published: (2014)

Transient DNMT1 suppression reveals hidden heritable marks in the genome
by: McGraw, Serge, et al.
Published: (2015)

Recurrent DNMT3A Mutations in Patients with Myelodysplastic Syndromes
by: Walter, Matthew J., et al.
Published: (2011)

Age‐dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK‐AGE study
by: Ciccarone, Fabio, et al.
Published: (2016)

Lsh Is Essential for Maintaining Global DNA Methylation Levels in Amphibia and Fish and Interacts Directly with Dnmt1
by: Dunican, Donncha S., et al.
Published: (2015)

Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy
by: Tang, Mingqing, et al.
Published: (2009)

Rare mutations in DNMT3A in myeloproliferative neoplasms and myelodysplastic syndromes
by: Brecqueville, M, et al.
Published: (2011)

Novel splice variants associated with one of the zebrafish dnmt3 genes
by: Smith, Tamara HL, et al.
Published: (2005)

Restricted mobility of Dnmt1 in preimplantation embryos: implications for epigenetic reprogramming
by: Grohmann, Maik, et al.
Published: (2005)

Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas
by: Gömöri, Éva, et al.
Published: (2012)

5-Aza-2′-deoxycytidine-induced genome rearrangements are mediated by DNMT1
by: Maslov, Alexander Y., et al.
Published: (2012)

Structure Analysis of Entamoeba histolytica DNMT2 (EhMeth)
by: Schulz, Eike C., et al.
Published: (2012)

DNMT1 Maintains Progenitor Function in Self-Renewing Somatic Tissue
by: Sen, George L., et al.
Published: (2010)