Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia

Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia

Mutations in the genetic sequence of the DNA de novo methyltransferase DNMT3A (DNA methyltransferase 3A) are found in many patients with acute myeloid leukemia (AML). They lead to dysfunction of DNMT3A protein and represent a marker for poor prognosis. Effects of genetic mutations can be mimicked by...

Full description

Bibliographic Details
Main Authors: Jost, E, Lin, Q, Weidner, C I, Wilop, S, Hoffmann, M, Walenda, T, Schemionek, M, Herrmann, O, Zenke, M, Brümmendorf, T H, Koschmieder, S, Wagner, W
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051212/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051212/

Similar Items