Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia

Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia

DNMT3B encodes a DNA methyltransferase implicated in aberrant epigenetic changes contributing to leukemogenesis. We tested whether DNMT3B expression, measured by NanoString nCounter assay, associates with outcome, gene- and microRNA-expression and DNA methylation profiles in 210 older (≥60 years) ad...

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Bibliographic Details
Main Authors: Niederwieser, Christian, Kohlschmidt, Jessica, Volinia, Stefano, Whitman, Susan P., Metzeler, Klaus H., Eisfeld, Ann-Kathrin, Maharry, Kati, Yan, Pearlly, Frankhouser, David, Becker, Heiko, Schwind, Sebastian, Carroll, Andrew J., Nicolet, Deedra, Mendler, Jason H., Curfman, John P., Wu, Yue-Zhong, Baer, Maria R., Powell, Bayard L., Kolitz, Jonathan E., Moore, Joseph O., Carter, Thomas H., Bundschuh, Ralf, Larson, Richard A., Stone, Richard M., Mrózek, Krzysztof, Marcucci, Guido, Bloomfield, Clara D.
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351165/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351165/

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