Site- and allele-specific polycomb dysregulation in T-cell leukaemia

Site- and allele-specific polycomb dysregulation in T-cell leukaemia

T-cell acute lymphoblastic leukaemias (T-ALL) are aggressive malignant proliferations characterized by high relapse rates and great genetic heterogeneity. TAL1 is amongst the most frequently deregulated oncogenes. Yet, over half of the TAL1+ cases lack TAL1 lesions, suggesting unrecognized (epi)gene...

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Main Authors: Navarro, Jean-Marc, Touzart, Aurore, Pradel, Lydie C., Loosveld, Marie, Koubi, Myriam, Fenouil, Romain, Le Noir, Sandrine, Maqbool, Muhammad Ahmad, Morgado, Ester, Gregoire, Claude, Jaeger, Sebastien, Mamessier, Emilie, Pignon, Charles, Hacein-Bey-Abina, Salima, Malissen, Bernard, Gut, Marta, Gut, Ivo G., Dombret, Hervé, Macintyre, Elizabeth A., Howe, Steven J., Gaspar, H. Bobby, Thrasher, Adrian J., Ifrah, Norbert, Payet-Bornet, Dominique, Duprez, Estelle, Andrau, Jean-Christophe, Asnafi, Vahid, Nadel, Bertrand
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317503/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317503/

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