Dynamic recruitment of Ets1 to both nucleosome-occupied and -depleted enhancer regions mediates a transcriptional program switch during early T-cell differentiation

Dynamic recruitment of Ets1 to both nucleosome-occupied and -depleted enhancer regions mediates a transcriptional program switch during early T-cell differentiation

Ets1 is a sequence-specific transcription factor that plays an important role during hematopoiesis, and is essential for the transition of CD4−/CD8− double negative (DN) to CD4+/CD8+ double positive (DP) thymocytes. Using genome-wide and functional approaches, we investigated the binding properties,...

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Bibliographic Details
Main Authors: Cauchy, Pierre, Maqbool, Muhammad A., Zacarias-Cabeza, Joaquin, Vanhille, Laurent, Koch, Frederic, Fenouil, Romain, Gut, Marta, Gut, Ivo, Santana, Maria A., Griffon, Aurélien, Imbert, Jean, Moraes-Cabé, Carolina, Bories, Jean-Christophe, Ferrier, Pierre, Spicuglia, Salvatore, Andrau, Jean-Christophe
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856961/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856961/

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