Optimized Whole-Genome Amplification Strategy for Extremely AT-Biased Template

Pathogen genome sequencing directly from clinical samples is quickly gaining importance in genetic and medical research studies. However, low DNA yield from blood-borne pathogens is often a limiting factor. The problem worsens in extremely base-biased genomes such as the AT-rich Plasmodium falciparu...

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Bibliographic Details
Main Authors: Oyola, Samuel O., Manske, Magnus, Campino, Susana, Claessens, Antoine, Hamilton, William L., Kekre, Mihir, Drury, Eleanor, Mead, Daniel, Gu, Yong, Miles, Alistair, MacInnis, Bronwyn, Newbold, Chris, Berriman, Matthew, Kwiatkowski, Dominic P.
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263299/