Further Improvements to Linear Mixed Models for Genome-Wide Association Studies

Further Improvements to Linear Mixed Models for Genome-Wide Association Studies

We examine improvements to the linear mixed model (LMM) that better correct for population structure and family relatedness in genome-wide association studies (GWAS). LMMs rely on the estimation of a genetic similarity matrix (GSM), which encodes the pairwise similarity between every two individuals...

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Bibliographic Details
Main Authors: Widmer, Christian, Lippert, Christoph, Weissbrod, Omer, Fusi, Nicolo, Kadie, Carl, Davidson, Robert, Listgarten, Jennifer, Heckerman, David
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230738/

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