Warped linear mixed models for the genetic analysis of transformed phenotypes

Linear mixed models (LMMs) are a powerful and established tool for studying genotype–phenotype relationships. A limitation of the LMM is that the model assumes Gaussian distributed residuals, a requirement that rarely holds in practice. Violations of this assumption can lead to false conclusions and...

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Bibliographic Details
Main Authors: Fusi, Nicolo, Lippert, Christoph, Lawrence, Neil D., Stegle, Oliver
Format: Online
Language:English
Published: Nature Pub. Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199105/