Metabolic memory of ß-cells controls insulin secretion and is mediated by CaMKIIa
Ca2+/calmodulin-dependent protein kinase II (CaMKII) functions both in regulation of insulin secretion and neurotransmitter release through common downstream mediators. Therefore, we hypothesized that pancreatic ß-cells acquire and store the information contained in calcium pulses as a form of “meta...
Main Authors: | Santos, Gustavo Jorge dos, Ferreira, Sandra Mara, Ortis, Fernanda, Rezende, Luiz Fernando, Li, Chengyang, Naji, Ali, Carneiro, Everardo Magalhães, Kaestner, Klaus H., Boschero, Antonio Carlos |
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Format: | Online |
Language: | English |
Published: |
Elsevier
2014
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060215/ |
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