Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic ß-cells
Acute insulin-releasing actions of amino acids have been studied in detail, but comparatively little is known about the ß-cell effects of long-term exposure to amino acids. The present study examined the effects of prolonged exposure of ß-cells to the metabolizable amino acid L-alanine. Basal insuli...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Published: |
Portland Press
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/6238 |