Acquired Deficiency of A20 Results in Rapid Apoptosis, Systemic Inflammation, and Abnormal Hematopoietic Stem Cell Function

Acquired Deficiency of A20 Results in Rapid Apoptosis, Systemic Inflammation, and Abnormal Hematopoietic Stem Cell Function

A20 is a negative regulator of NF-κB, and mutational loss of A20 expression is involved in the pathogenesis of autoimmune diseases and B-cell lymphomas. To clarify the role of A20 in adult hematopoiesis, we generated conditional A20 knockout mice (A20flox/flox) and crossed them with Mx–1Cre (MxCre +...

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Main Authors: Nagamachi, Akiko, Nakata, Yuichiro, Ueda, Takeshi, Yamasaki, Norimasa, Ebihara, Yasuhiro, Tsuji, Kohichiro, Honda, Zen-ichiro, Takubo, Keiyo, Suda, Toshio, Oda, Hideaki, Inaba, Toshiya, Honda, Hiroaki
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909109/

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