TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms

TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms

A cytokine/stress signaling kinase Tak1 (Map3k7) deficiency is known to impair hematopoietic progenitor cells. However, the role of TAK1 signaling in the stem cell function of the hematopoietic system is not yet well defined. Here we characterized hematopoietic stem cells (HSCs) harboring deletion o...

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Bibliographic Details
Main Authors: Takaesu, Giichi, Inagaki, Maiko, Takubo, Keiyo, Mishina, Yuji, Hess, Paul R., Dean, Gregg A., Yoshimura, Akihiko, Matsumoto, Kunihiro, Suda, Toshio, Ninomiya-Tsuji, Jun
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511369/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511369/

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