Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency

Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency

Polycomb repressive complex 2 (PRC2) participates in transcriptional repression through methylation of histone H3K27. The WD-repeat protein embryonic ectoderm development (EED) is a non-catalytic but an essential component of PRC2 and its mutations were identified in hematopoietic malignancies. To c...

Full description

Bibliographic Details
Main Authors: Ikeda, Kenichiro, Ueda, Takeshi, Yamasaki, Norimasa, Nakata, Yuichiro, Sera, Yasuyuki, Nagamachi, Akiko, Miyama, Takahiko, Kobayashi, Hiroshi, Takubo, Keiyo, Kanai, Akinori, Oda, Hideaki, Wolff, Linda, Honda, Zen-ichiro, Ichinohe, Tatsuo, Matsubara, Akio, Suda, Toshio, Inaba, Toshiya, Honda, Hiroaki
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949429/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949429/

Similar Items