Prevention of Obesity and Insulin Resistance by Estrogens Requires ERα Activation Function-2 (ERαAF-2), Whereas ERαAF-1 Is Dispensable

Prevention of Obesity and Insulin Resistance by Estrogens Requires ERα Activation Function-2 (ERαAF-2), Whereas ERαAF-1 Is Dispensable

The beneficial metabolic actions of estrogen-based therapies are mainly mediated by estrogen receptor α (ERα), a nuclear receptor that regulates gene transcription through two activation functions (AFs): AF-1 and AF-2. Using mouse models deleted electively for ERαAF-1 (ERαAF-1°) or ERαAF-2 (ERαAF-2°...

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Bibliographic Details
Main Authors: Handgraaf, Sandra, Riant, Elodie, Fabre, Aurélie, Waget, Aurélie, Burcelin, Rémy, Lière, Philippe, Krust, Andrée, Chambon, Pierre, Arnal, Jean-François, Gourdy, Pierre
Format: Online
Language:English
Published: American Diabetes Association 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837069/

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