Aurora-A Mitotic Kinase Induces Endocrine Resistance through Down-Regulation of ERα Expression in Initially ERα+ Breast Cancer Cells

Aurora-A Mitotic Kinase Induces Endocrine Resistance through Down-Regulation of ERα Expression in Initially ERα+ Breast Cancer Cells

Development of endocrine resistance during tumor progression represents a major challenge in the management of estrogen receptor alpha (ERα) positive breast tumors and is an area under intense investigation. Although the underlying mechanisms are still poorly understood, many studies point towards t...

Full description

Bibliographic Details
Main Authors: Opyrchal, Mateusz, Salisbury, Jeffrey L., Zhang, Shuya, McCubrey, James, Hawse, John, Goetz, Mattew P., Lomberk, Gwen A., Haddad, Tufia, Degnim, Amy, Lange, Carol, Ingle, James N., Galanis, Evanthia, D'Assoro, Antonino B.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016211/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016211/

Similar Items