SERMs have substance-specific effects on bone, and these effects are mediated via ERαAF-1 in female mice

SERMs have substance-specific effects on bone, and these effects are mediated via ERαAF-1 in female mice

The bone-sparing effect of estrogens is mediated primarily via estrogen receptor (ER)α, which stimulates gene transcription through activation function (AF)-1 and AF-2. The role of ERαAF-1 for the estradiol (E2) effects is tissue specific. The selective ER modulators (SERMs) raloxifene (Ral), lasofo...

Full description

Bibliographic Details
Main Authors: Börjesson, Anna E., Farman, Helen H., Movérare-Skrtic, Sofia, Engdahl, Cecilia, Antal, Maria Cristina, Koskela, Antti, Tuukkanen, Juha, Carlsten, Hans, Krust, Andrée, Chambon, Pierre, Sjögren, Klara, Lagerquist, Marie K., Windahl, Sara H., Ohlsson, Claes
Format: Online
Language:English
Published: American Physiological Society 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935145/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935145/

Similar Items