The Heme Oxygenase-1 Inducer THI-56 Negatively Regulates iNOS Expression and HMGB1 Release in LPS-Activated RAW 264.7 Cells and CLP-Induced Septic Mice

The Heme Oxygenase-1 Inducer THI-56 Negatively Regulates iNOS Expression and HMGB1 Release in LPS-Activated RAW 264.7 Cells and CLP-Induced Septic Mice

The nuclear DNA binding protein high mobility group box 1 (HMGB1) has recently been suggested to act as a late mediator of septic shock. The effect of ((S)-6,7-dihydroxy-1-(4-hydroxynaphthylmethyl)-1,2,3,4-tetrahydroisoquinoline alkaloid, also known as THI-56, in an experimental model of sepsis was...

Full description

Bibliographic Details
Main Authors:	Park, Eun Jung, Jang, Hwa Jin, Tsoyi, Konstantin, Kim, Young Min, Park, Sang Won, Kim, Hye Jung, Lee, Jae Heun, Chang, Ki Churl
Format:	Online
Language:	English
Published:	Public Library of Science 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789711/

Similar Items

Ginsenoside Rd inhibits the expressions of iNOS and COX-2 by suppressing NF-κB in LPS-stimulated RAW264.7 cells and mouse liver
by: Kim, Dae Hyun, et al.
Published: (2013)

Adiponectin Inhibits LPS-Induced HMGB1 Release through an AMP Kinase and Heme Oxygenase-1-Dependent Pathway in RAW 264 Macrophage Cells
by: Elfeky, Mohamed, et al.
Published: (2016)

iNOS activity is critical for the clearance of Burkholderia mallei from infected RAW 264.7 murine macrophages
by: Brett, Paul J, et al.
Published: (2008)

Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways
by: Wu, Chuanhong, et al.
Published: (2015)

Isoegomaketone Upregulates Heme Oxygenase-1 in RAW264.7 Cells via ROS/p38 MAPK/Nrf2 Pathway
by: Jin, Chang Hyun, et al.
Published: (2016)

Induction of Inflammatory Responses by Carbon Fullerene (C60) in Cultured RAW264.7 Cells and in Intraperitoneally Injected Mice
by: Park, Eun-Jung, et al.
Published: (2010)

YC-1 induces lipid droplet formation in RAW 264.7 macrophages
by: Tsui, Leo, et al.
Published: (2016)

CD83 expression induced by CpG-DNA stimulation in a macrophage cell line RAW 264.7
by: Park, Min Chul, et al.
Published: (2013)

PLA2 antagonists suppress inducible nitric oxide synthase and inducible cyclooxygenase in lipopolysaccharide-induced Raw264.7 cells
by: Baek, S-H, et al.
Published: (1999)

Aromadendrin Inhibits Lipopolysaccharide-Induced Nuclear Translocation of NF-κB and Phosphorylation of JNK in RAW 264.7 Macrophage Cells
by: Lee, Jae-Won, et al.
Published: (2013)

Suppression of Heme Oxygenase-1 by Prostaglandin E2-Protein Kinase A-A-Kinase Anchoring Protein Signaling Is Central for Augmented Cyclooxygenase-2 Expression in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages
by: Lee, Jae-Hyoung, et al.
Published: (2013)

The effects of Lycii Radicis Cortex on RANKL-induced osteoclast differentiation and activation in RAW 264.7 cells
by: KIM, JAE-HYUN, et al.
Published: (2016)

Anti-inflammatory effects of oroxylin A on RAW 264.7 mouse macrophages induced with polyinosinic-polycytidylic acid
by: LEE, JI YOUNG, et al.
Published: (2016)

The uptake of tocopherols by RAW 264.7 macrophages
by: Gao, Rong, et al.
Published: (2002)

Okanin, a chalcone found in the genus Bidens, and 3-penten-2-one inhibit inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with lipopolysaccharide
by: Kil, Jin-Sang, et al.
Published: (2012)

Paraquat Induces Apoptosis through a Mitochondria-Dependent Pathway in RAW264.7 Cells
by: Jang, Yeo Jin, et al.
Published: (2015)

Silibinin Inhibits LPS-Induced Macrophage Activation by Blocking p38 MAPK in RAW 264.7 Cells
by: Youn, Cha Kyung, et al.
Published: (2013)

Hypochoeris radicata attenuates LPS-induced inflammation by suppressing p38, ERK, and JNK phosphorylation in RAW 264.7 macrophages
by: Kim, Min-Jin, et al.
Published: (2014)

Resveratrol activates AMPK and suppresses LPS-induced NF-κB-dependent COX-2 activation in RAW 264.7 macrophage cells
by: Yi, Chin-Ok, et al.
Published: (2011)

The Anti-Inflammatory Effects and Mechanisms of Eupafolin in Lipopolysaccharide-Induced Inflammatory Responses in RAW264.7 Macrophages
by: Chen, Chin-Chaun, et al.
Published: (2016)

Avicularin Inhibits Lipopolysaccharide-Induced Inflammatory Response by Suppressing ERK Phosphorylation in RAW 264.7 Macrophages
by: Vo, Van Anh, et al.
Published: (2012)

Taurine chloramine protects RAW 264.7 macrophages against hydrogen peroxide-induced apoptosis by increasing antioxidants
by: Piao, Shuyu, et al.
Published: (2011)

β-Lapachone, a substrate of NAD(P)H:quinone oxidoreductase, induces anti-inflammatory heme oxygenase-1 via AMP-activated protein kinase activation in RAW264.7 macrophages
by: Byun, Seung Jae, et al.
Published: (2013)

Effects of 3-(2-Hydroxyphenyl)-1-(5-methyl-furan-2-y-l) propenone (HMP) upon signalling pathways of lipopolysaccharide-induced iNOS synthesis in RAW 264.7 cells.
by: Choi, Yi Liew, et al.
Published: (2011)

PEP-1-PON1 Protein Regulates Inflammatory Response in Raw 264.7 Macrophages and Ameliorates Inflammation in a TPA-Induced Animal Model
by: Kim, Mi Jin, et al.
Published: (2014)

The Nuclear Orphan Receptor NR4A1 is Involved in the Apoptotic Pathway Induced by LPS and Simvastatin in RAW 264.7 Macrophages
by: Kim, Yong Chan, et al.
Published: (2014)

β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo
by: Syam, Suvitha, et al.
Published: (2014)

β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo
by: Syam, S., et al.
Published: (2014)

Effect of Egg White Combined with Chalcanthite on Lipopolysaccharide induced Inflammatory Cytokine Expression in RAW 264.7 cells
by: Choi, Eun-A, et al.
Published: (2012)

Inhibitory Effects of Benzaldehyde Derivatives from the Marine Fungus Eurotium sp. SF-5989 on Inflammatory Mediators via the Induction of Heme Oxygenase-1 in Lipopolysaccharide-Stimulated RAW264.7 Macrophages
by: Kim, Kyoung-Su, et al.
Published: (2014)

Quercetin-3-O-β-D-Glucuronide Suppresses Lipopolysaccharide-Induced JNK and ERK Phosphorylation in LPS-Challenged RAW264.7 Cells
by: Park, Jin-Young, et al.
Published: (2016)

Methyl p-Hydroxycinnamate Suppresses Lipopolysaccharide-Induced Inflammatory Responses through Akt Phosphorylation in RAW264.7 Cells
by: Vo, Van Anh, et al.
Published: (2014)

Naringin Decreases TNF-α and HMGB1 Release from LPS-Stimulated Macrophages and Improves Survival in a CLP-Induced Sepsis Mice
by: Gil, Minchan, et al.
Published: (2016)

Anti-inflammatory effect of ozonated krill (Euphausia superba) oil in lipopolysaccharide-stimulated RAW 264.7 macrophages
by: Hong-Deok Kim, et al.
Published: (2018-06-01)

Preventive effect of Ligularia fischeri on inhibition of nitric oxide in lipopolysaccharide-stimulated RAW 264.7 macrophages depending on cooking method
by: Park, Hee-Sook, et al.
Published: (2014)

Anti-inflammatory effects of Cordyceps mycelium (Paecilomyces hepiali, CBG-CS-2) in Raw264.7 murine macrophages
by: Park, Seong-Yeol, et al.
Published: (2014)

Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP Kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophages
by: Lee, Jong Kwon, et al.
Published: (2012)

Phosphorylation of Akt Mediates Anti-Inflammatory Activity of 1-p-Coumaroyl β-D-Glucoside Against Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells
by: Vo, Van Anh, et al.
Published: (2014)

Immune-Enhancement and Anti-Inflammatory Activities of Fatty Acids Extracted from Halocynthia aurantium Tunic in RAW264.7 Cells
by: Chaiwat Monmai, et al.
Published: (2018-09-01)

Korean Red Ginseng Saponin Fraction Downregulates Proinflammatory Mediators in LPS Stimulated RAW264.7 Cells and Protects Mice against Endotoxic Shock
by: Yayeh, Taddessee, et al.
Published: (2012)