Minimizing the Maximum Expected Sample Size in Two-Stage Phase II Clinical Trials with Continuous Outcomes
Two-stage designs are commonly used for Phase II trials. Optimal two-stage designs have the lowest expected sample size for a specific treatment effect, for example, the null value, but can perform poorly if the true treatment effect differs. Here we introduce a design for continuous treatment respo...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Taylor & Francis
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662082/ |