A review and re-interpretation of a group-sequential approach to sample size re-estimation in two-stage trials
In this paper, we review the adaptive design methodology of Li et al. (Biostatistics 3:277–287) for two-stage trials with mid-trial sample size adjustment. We argue that it is closer in principle to a group sequential design, in spite of its obvious adaptive element. Several extensions are proposed...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
BlackWell Publishing Ltd
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288989/ |