Reduction of Connexin36 Content by ICER-1 Contributes to Insulin-Secreting Cells Apoptosis Induced by Oxidized LDL Particles

Reduction of Connexin36 Content by ICER-1 Contributes to Insulin-Secreting Cells Apoptosis Induced by Oxidized LDL Particles

Connexin36 (Cx36), a trans-membrane protein that forms gap junctions between insulin-secreting beta-cells in the Langerhans islets, contributes to the proper control of insulin secretion and beta-cell survival. Hypercholesterolemia and pro-atherogenic low density lipoproteins (LDL) contribute to bet...

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Bibliographic Details
Main Authors: Haefliger, Jacques-Antoine, Martin, David, Favre, Dimitri, Petremand, Yannick, Mazzolai, Lucia, Abderrahmani, Amar, Meda, Paolo, Waeber, Gérard, Allagnat, Florent
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559396/

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