Specific Silencing of the REST Target Genes in Insulin-Secreting Cells Uncovers Their Participation in Beta Cell Survival

Specific Silencing of the REST Target Genes in Insulin-Secreting Cells Uncovers Their Participation in Beta Cell Survival

The absence of the transcriptional repressor RE-1 Silencing Transcription Factor (REST) in insulin-secreting beta cells is a major cue for the specific expression of a large number of genes. These REST target genes were largely ascribed to a function of neurotransmission in a neuronal context, where...

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Bibliographic Details
Main Authors: Martin, David, Allagnat, Florent, Gesina, Emilie, Caille, Dorothee, Gjinovci, Asllan, Waeber, Gerard, Meda, Paolo, Haefliger, Jacques-Antoine
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447792/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447792/

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