Matrix IGF-1 regulates bone mass by activation of mTOR in mesenchymal stem cells

Matrix IGF-1 regulates bone mass by activation of mTOR in mesenchymal stem cells

Insulin-like growth factor 1 (IGF-1), the most abundant growth factor in the bone matrix, regulates bone mass in adulthood. We report that IGF-1 released from bone matrix stimulates osteoblastic differentiation of mesenchymal stem cell (MSCs) by activation of mTOR during bone remodeling. Mice knocko...

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Bibliographic Details
Main Authors: Xian, Lingling, Wu, Xiangwei, Pang, Lijuan, Lou, Michael, Rosen, Clifford, Qiu, Tao, Crane, Janet, Frassica, Frank, Zhang, Liming, Rodriguez, Juan Pablo, Jia, Xiaofeng, Yakar, Shoshana, Xuan, Shouhong, Efstratiadis, Argiris, Wan, Mei, Cao, Xu
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438316/

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