Serum IGF-1 Affects Skeletal Acquisition in a Temporal and Compartment-Specific Manner

Insulin-like growth factor-1 (IGF-1) plays a critical role in the development of the growing skeleton by establishing both longitudinal and transverse bone accrual. IGF-1 has also been implicated in the maintenance of bone mass during late adulthood and aging, as decreases in serum IGF-1 levels appe...

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Bibliographic Details
Main Authors: Courtland, Hayden-William, Elis, Sebastien, Wu, Yingjie, Sun, Hui, Rosen, Clifford J., Jepsen, Karl J., Yakar, Shoshana
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060807/