Human melanoma-specific CD8+ T-cells from metastases are capable of antigen-specific degranulation and cytolysis directly ex vivo

Human melanoma-specific CD8+ T-cells from metastases are capable of antigen-specific degranulation and cytolysis directly ex vivo

The relatively low frequencies of tumor Ag-specific T-cells in PBMC and metastases from cancer patients have long precluded the analysis of their direct ex vivo cytolytic capacity. Using a new composite technique that works well with low cell numbers, we aimed at determining the functional competenc...

Full description

Bibliographic Details
Main Authors: Mahnke, Yolanda D., Devevre, Estelle, Baumgaertner, Petra, Matter, Maurice, Rufer, Nathalie, Romero, Pedro, Speiser, Daniel E.
Format: Online
Language:English
Published: Landes Bioscience 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382891/

Similar Items

Similar Items