Extended Co-Expression of Inhibitory Receptors by Human CD8 T-Cells Depending on Differentiation, Antigen-Specificity and Anatomical Localization

Extended Co-Expression of Inhibitory Receptors by Human CD8 T-Cells Depending on Differentiation, Antigen-Specificity and Anatomical Localization

Inhibitory receptors mediate CD8 T-cell hyporesponsiveness against cancer and infectious diseases. PD-1 and CTLA-4 have been extensively studied, and blocking antibodies have already shown clinical benefit for cancer patients. Only little is known on extended co-expression of inhibitory receptors an...

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Bibliographic Details
Main Authors: Baitsch, Lukas, Legat, Amandine, Barba, Leticia, Fuertes Marraco, Silvia A., Rivals, Jean-Paul, Baumgaertner, Petra, Christiansen-Jucht, Céline, Bouzourene, Hanifa, Rimoldi, Donata, Pircher, Hanspeter, Rufer, Nathalie, Matter, Maurice, Michielin, Olivier, Speiser, Daniel E.
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275569/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275569/

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