Estradiol Triggers Sonic-hedgehog–induced Angiogenesis During Peripheral Nerve Regeneration by Downregulating Hedgehog-interacting Protein

Estradiol Triggers Sonic-hedgehog–induced Angiogenesis During Peripheral Nerve Regeneration by Downregulating Hedgehog-interacting Protein

Both estradiol (E2) and Sonic Hedgehog (Shh) contribute to angiogenesis and nerve regeneration. Here, we investigated whether E2 improves the recovery of injured nerves by downregulating the Shh-inhibitor Hedgehog-interacting Protein (HIP) and increasing Shh-induced angiogenesis. Mice were treated w...

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Bibliographic Details
Main Authors: Sekiguchi, Haruki, Ii, Masaaki, Jujo, Kentaro, Renault, Marie-Ange, Thorne, Tina, Clarke, Trevor, Ito, Aiko, Tanaka, Toshikazu, Klyachko, Ekaterina, Tabata, Yasuhiko, Hagiwara, Nobuhisa, Losordo, Douglas W.
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319330/

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