The inflammasome adaptor ASC regulates adaptive immune cell functions by controlling DOCK2-mediated Rac activation and actin polymerization

The inflammasome adaptor ASC regulates adaptive immune cell functions by controlling DOCK2-mediated Rac activation and actin polymerization

The adaptor protein ASC contributes to innate immunity through the assembly of caspase-1-activating inflammasome complexes. We demonstrate that ASC plays an inflammasome-independent cell-intrinsic role in adaptive immune cells. Asc−/− mice displayed defective antigen presentation by dendritic cells...

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Bibliographic Details
Main Authors: Ippagunta, Sirish K., Malireddi, R. K. Subbarao, Shaw, Patrick J., Neale, Geoffrey A., Vande Walle, Lieselotte, Green, Douglas R., Fukui, Yoshinori, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178750/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178750/

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