Mechanism of AMPK Suppression of LXR-dependent Srebp-1c Transcription

Mechanism of AMPK Suppression of LXR-dependent Srebp-1c Transcription

Activation of AMP-activated protein kinase (AMPK) inhibits hepatic fatty acid synthesis by suppressing sterol regulatory element-binding protein (SREBP)-1c, a master regulator of hepatic lipogenic gene expression. Using a model cell line rat hepatoma McA-RH7777 (CRL-1601) that mimics the behavior of...

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Bibliographic Details
Main Authors:	Yap, Fuichi, Craddock, Lauren, Yang, Jian
Format:	Online
Language:	English
Published:	Ivyspring International Publisher 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107472/

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