Mechanism of AMPK Suppression of LXR-dependent Srebp-1c Transcription
Activation of AMP-activated protein kinase (AMPK) inhibits hepatic fatty acid synthesis by suppressing sterol regulatory element-binding protein (SREBP)-1c, a master regulator of hepatic lipogenic gene expression. Using a model cell line rat hepatoma McA-RH7777 (CRL-1601) that mimics the behavior of...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Ivyspring International Publisher
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107472/ |