Monoclonal Antibodies against Nucleophosmin Mutants: Potentials for the Detection of Acute Myeloid Leukemia

Monoclonal Antibodies against Nucleophosmin Mutants: Potentials for the Detection of Acute Myeloid Leukemia

Nucleophosmin (NPM1) gene mutations resulting in cytoplasmic delocalization of Nucleophosmin (NPMc+) are the most common genetic alteration in acute myeloid leukemia (AML). Here, we attempted to prepare monoclonal antibodies (mAbs) against NPM1 mutation A (NPM-mA) and investigated the mAbs' cli...

Full description

Bibliographic Details
Main Authors:	Tan, Shi, Zhang, Ling, Zhong, Xiao-Ming, Yang, Zai-Lin, Zhao, Liu-Yang, Gao, Yu-Jie, Shao, Hui-Yuan, Qin, Feng-Xian, Chen, Xian-Chun, Zhang, Hui-Juan, Chen, Hui, Wang, Li
Format:	Online
Language:	English
Published:	Ivyspring International Publisher 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100738/

Similar Items

Monoclonal Antibodies against Nucleophosmin Mutants: Potentials for the Detection of Acute Myeloid Leukemia
by: Shi Tan, Ling Zhang, Xiao-Ming Zhong, Zai-Lin Yang, Liu-Yang Zhao, Yu-Jie Gao, Hui-Yuan Shao, Feng-Xian Qin, Xian-Chun Chen, Hui-Juan Zhang, Hui Chen, Li Wang
Published: (2011-01-01)

Quantitative Detection of Circulating Nucleophosmin Mutations DNA in the Plasma of Patients with Acute Myeloid Leukemia
by: Quan, Jing, et al.
Published: (2015)

Nucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK Signaling
by: Xian, Jingrong, et al.
Published: (2016)

A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice
by: Mupo, A, et al.
Published: (2013)

Nucleophosmin Mutations Induce Chemosensitivity in THP-1 Leukemia Cells by Suppressing NF-κB Activity and Regulating Bax/Bcl-2 Expression
by: Zhang, Shuaishuai, et al.
Published: (2016)

Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice
by: Vassiliou, George S., et al.
Published: (2011)

Altered HLA Class I Profile Associated with Type A/D Nucleophosmin Mutation Points to Possible Anti-Nucleophosmin Immune Response in Acute Myeloid Leukemia
by: Kuželová, Kateřina, et al.
Published: (2015)

Detection of nucleophosmin and FMS-like tyrosine kinase-3 gene mutations in acute myeloid leukemia
by: Pazhakh, Vahid, et al.
Published: (2011)

Prognostic Impact of Nucleophosmin 1 (NPM1) Gene Mutations in Egyptian Acute Myeloid Leukemia Patients
by: Zidan, Magda, et al.
Published: (2013)

The Role of Monoclonal Antibodies in the Management of Leukemia
by: Al-Ameri, Ali, et al.
Published: (2010)

Fluorouracil Selectively Enriches Stem-like Leukemic Cells in a Leukemic Cell Line
by: Ling Zhang, Song Yang, Yu-Juan He, Hui-Yuan Shao, Li Wang, Hui Chen, Yu-Jie Gao, Feng-Xian Qing, Xian-Chun Chen, Liu-Yang Zhao, Shi Tan
Published: (2010-01-01)

Knockdown of NPM1 by RNA Interference Inhibits Cells Proliferation and Induces Apoptosis in Leukemic Cell Line
by: Qin, Feng-Xian, et al.
Published: (2011)

Knockdown of NPM1 by RNA Interference Inhibits Cells Proliferation and Induces Apoptosis in Leukemic Cell Line
by: Feng-Xian Qin, Hui-Yuan Shao, Xian-Chun Chen, Shi Tan, Hui-Juan Zhang, Zong-Yu Miao, Li Wang, Hui-Chen, Ling Zhang
Published: (2011-01-01)

Mutant monoclonal antibodies with alterations in biological functions
by: Yelton, DE, et al.
Published: (1982)

Expression of Nucleophosmin/NPM1 correlates with migration and invasiveness of colon cancer cells
by: Liu, Yan, et al.
Published: (2012)

Humoral autoimmune response to nucleophosmin in the immunodiagnosis of hepatocellular carcinoma
by: LIU, MEI, et al.
Published: (2015)

A redox mechanism underlying nucleolar stress sensing by nucleophosmin
by: Yang, Kai, et al.
Published: (2016)

Poor prognosis of nucleophosmin overexpression in solid tumors: a meta-analysis
by: Siying Chen, et al.
Published: (2018-08-01)

A new monoclonal antibody detects downregulation of protein tyrosine phosphatase receptor type γ in chronic myeloid leukemia patients
by: Marzia Vezzalini, et al.
Published: (2017-06-01)

Pegylated Gold Nanoparticles Induce Apoptosis in Human Chronic Myeloid Leukemia Cells
by: Huang, Yu-Chuen, et al.
Published: (2014)

Knockdown of nucleophosmin induces S-phase arrest in HepG2 cells
by: Wang, Qing-Qing, et al.
Published: (2011)

Imatinib-induced decompensated heart failure in an elderly patient with chronic myeloid leukemia: case report and literature review
by: Ran, Hai-Hong, et al.
Published: (2012)

Notch2 inhibits proliferation of chronic myeloid leukemia cells
by: YANG, ZESONG, et al.
Published: (2013)

Acute appendicitis caused by acute myeloid leukemia
by: Zhang, Shanxiang, et al.
Published: (2014)

Significance of nucleophosmin1 (NPM1) gene mutation status on acute myeloid leukaemia patients with normal karyotype in South India
by: Sureshkumar, R, et al.
Published: (2014)

Nucleophosmin mutation analysis in acute myeloid leukaemia: Immunohistochemistry as a surrogate for molecular techniques
by: Chopra, Anita, et al.
Published: (2016)

Prognostic value of miR-96 in patients with acute myeloid leukemia
by: Zhao, Jiangning, et al.
Published: (2014)

Regulation of subcellular distribution and oncogenic potential of nucleophosmin by plakoglobin
by: Lam, L, et al.
Published: (2012)

Molecules that target nucleophosmin for cancer treatment: an update
by: Di Matteo, Adele, et al.
Published: (2016)

Nucleophosmin: from structure and function to disease development
by: Box, Joseph K., et al.
Published: (2016)

Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells
by: Song, Ping, et al.
Published: (2015)

The HER2 inhibitor TAK165 Sensitizes Human Acute Myeloid Leukemia Cells to Retinoic Acid-Induced Myeloid Differentiation by activating MEK/ERK mediated RARα/STAT1 axis
by: Shao, Xuejing, et al.
Published: (2016)

miR-10a is aberrantly overexpressed in Nucleophosmin1 mutated acute myeloid leukaemia and its suppression induces cell death
by: Bryant, Adam, et al.
Published: (2012)

Optimized Expression and Purification of Humbug in Pichia pastoris and Its Monoclonal Antibody Preparation
by: HUYAN, Ting, et al.
Published: (2015)

Human monoclonal antibodies and monoclonal antibody multispecificity.
by: Campbell, A. M., et al.
Published: (1987)

Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport
by: Arregi, Igor, et al.
Published: (2015)

Phosphorylation of Nucleophosmin at Threonine 234/237 is associated with HCC metastasis
by: Ha Ching, Rachel Hiu, et al.
Published: (2015)

Frequent reconstitution of IDH2R140Q mutant clonal multilineage hematopoiesis following chemotherapy for acute myeloid leukemia
by: Wiseman, Daniel H., et al.
Published: (2016)

Therapy of murine leukemia with monoclonal antibody against a normal differentiation antigen
Published: (1983)

The Use of Monoclonal Antibodies in the Treatment of Autoimmune Complications of Chronic Lymphocytic Leukemia
by: Laurenti, Luca, et al.
Published: (2013)