Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice

Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice

Acute myeloid leukemia (AML) is a molecularly diverse malignancy with a poor prognosis, whose largest subgroup is characterized by somatic mutations in NPM1, the gene for Nucleophosmin1. These mutations, termed NPM1c, result in cytoplasmic dislocation of Nucleophosmin1 and are associated with distin...

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Bibliographic Details
Main Authors: Vassiliou, George S., Cooper, Jonathan L., Rad, Roland, Li, Juan, Rice, Stephen, Uren, Anthony, Rad, Lena, Ellis, Peter, Andrews, Rob, Banerjee, Ruby, Grove, Carolyn, Wang, Wei, Liu, Pentao, Wright, Penny, Arends, Mark, Bradley, Allan
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084174/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084174/

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