Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon

Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon

RNA interference (RNAi) mediated by small-interfering RNAs (siRNAs) is a highly effective gene-silencing mechanism with great potential for gene-therapeutic applications. siRNA agents also exert non-target-related biological effects and toxicities, including immune-system stimulation. Specifically,...

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Bibliographic Details
Main Authors:	Gondai, Takuma, Yamaguchi, Kazuya, Miyano-Kurosaki, Naoko, Habu, Yuichirou, Takaku, Hiroshi
Format:	Online
Language:	English
Published:	Oxford University Press 2008
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241887/

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