Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon
RNA interference (RNAi) mediated by small-interfering RNAs (siRNAs) is a highly effective gene-silencing mechanism with great potential for gene-therapeutic applications. siRNA agents also exert non-target-related biological effects and toxicities, including immune-system stimulation. Specifically,...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Oxford University Press
2008
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241887/ |