Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase

Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase

The conformational dynamics of the polymorphous trigger loop (TL) in RNA polymerase (RNAP) underlie multiple steps in the nucleotide addition cycle and diverse regulatory mechanisms. These mechanisms include nascent RNA hairpin-stabilized pausing, which inhibits TL folding into the trigger helices (...

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Bibliographic Details
Main Authors: Windgassen, Tricia A., Mooney, Rachel Anne, Nayak, Dhananjaya, Palangat, Murali, Zhang, Jinwei, Landick, Robert
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227799/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227799/

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