Characterization of dihydropyrimidine dehydrogenase in human colorectal tumours.

Characterization of dihydropyrimidine dehydrogenase in human colorectal tumours.

Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme for degradation of 5-fluorouracil (5-FU). DPD activity is highly variable in liver and peripheral mononuclear cells (PMNCs) and it has not been well studied in human tumours. Characterization of DPD in colorectal cancer is of clinical...

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Bibliographic Details
Main Authors:	McLeod, H. L., Sludden, J., Murray, G. I., Keenan, R. A., Davidson, A. I., Park, K., Koruth, M., Cassidy, J.
Format:	Online
Language:	English
Published:	Nature Publishing Group 1998
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151304/

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