Evaluation of Clinical Value of Single Nucleotide Polymorphisms of Dihydropyrimidine Dehydrogenase Gene to Predict 5-Fluorouracil Toxicity in 60 Colorectal Cancer Patients in China
Dihydropyrimidine dehydrogenase (DPD) activity could be affected by single nucleotide polymorphisms (SNPs), resulting in either no effect, partial or complete loss of DPD activity. To evaluate if SNPs of DPD can be used to predict 5-FU toxicity, we evaluated five SNPs of DPD (14G1A, G1156T, G2194A,...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Ivyspring International Publisher
2013
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675503/ |