Comparative evaluation of genetic toxicity patterns of carcinogens and noncarcinogens: strategies for predictive use of short-term assays.
The results of a recent comprehensive evaluation of the relationship between four measures of in vitro genetic toxicity and the capacity of the chemicals to induce neoplasia in rodents carry some important implications. The results showed that while the Salmonella mutagenesis assay detected only abo...
Main Authors: | Tennant, R W, Spalding, J W, Stasiewicz, S, Caspary, W D, Mason, J M, Resnick, M A |
---|---|
Format: | Online |
Language: | English |
Published: |
1987
|
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474441/ |
Similar Items
-
Predictions for the outcome of rodent carcinogenicity bioassays: identification of trans-species carcinogens and noncarcinogens.
by: Tennant, R W, et al.
Published: (1996) -
Mutagenic carcinogens and noncarcinogens in transgenic mice.
by: Günzel, P, et al.
Published: (1997) -
Alternative testing systems for evaluating noncarcinogenic, hematologic toxicity.
by: Parchment, R E
Published: (1998) -
Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models.
by: Tennant, R W, et al.
Published: (1995) -
Anomalous nonidentity between Salmonella genotoxicants and rodent carcinogens: nongenotoxic carcinogens and genotoxic noncarcinogens.
by: Yoshikawa, K
Published: (1996)