Metformin suppresses UHMWPE particle-induced osteolysis in the mouse calvaria by promoting polarization of macrophages to an anti-inflammatory phenotype

Metformin suppresses UHMWPE particle-induced osteolysis in the mouse calvaria by promoting polarization of macrophages to an anti-inflammatory phenotype

Abstract Background Implant failure remains a major obstacle to successful treatment via TJA. Periprosthetic osteolysis and aseptic loosening are considered as proof of wear debris-induced disruption of local regulatory mechanisms related to excessive bone resorption associated with osteolysis and t...

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Bibliographic Details
Main Authors: Zhao Yan, Xiaoxi Tian, Jinyu Zhu, Zifan Lu, Lifeng Yu, Dawei Zhang, Yanwu Liu, Chongfei Yang, Qingsheng Zhu, Xiaorui Cao
Format: Article
Language:English
Published: BioMed Central 2018-05-01
Series:Molecular Medicine
Subjects:
Inflammation
Osteoclasts
AMPK
Macrophage
Osteolysis
Online Access:http://link.springer.com/article/10.1186/s10020-018-0013-x

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