Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1β Stimulated Human Chondrocytes

Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1β Stimulated Human Chondrocytes

Background/Aims: Butein (2’,3,4,4’-Tetrahydroxychalcone), a polyphenol produced by several plants including Butea monoserpma, has been reported to exert potent anti-inflammatory activity but the mechanism remains unknown. In the present work we investigated the mechanism of Butein-mediated suppressi...

Full description

Bibliographic Details
Main Authors: Mohammad Y. Ansari, Nashrah Ahmad, Tariq M. Haqqi
Format: Article
Language:English
Published: Karger Publishers 2018-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Butein
Osteoarthritis
Autophagy
Inflammation
AMPK
mTOR
TSC2
ULK1
Online Access:https://www.karger.com/Article/FullText/493225

Internet

https://www.karger.com/Article/FullText/493225

Similar Items