Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling

Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling

Abstract Background Arhalofenate acid, the active acid form of arhalofenate, is a non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand, with uricosuric activity via URAT1 inhibition. Phase II studies revealed decreased acute arthritis flares in arhalofenate-treated gout compared w...

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Bibliographic Details
Main Authors: Charles McWherter, Yun-Jung Choi, Ramon L. Serrano, Sushil K. Mahata, Robert Terkeltaub, Ru Liu-Bryan
Format: Article
Language:English
Published: BioMed Central 2018-09-01
Series:Arthritis Research & Therapy
Subjects:
Gout
Inflammation
AMPK
Mitochondria
Autophagy flux
Online Access:http://link.springer.com/article/10.1186/s13075-018-1699-4

Internet

http://link.springer.com/article/10.1186/s13075-018-1699-4

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