Hypoxia-activated prodrugs: paths forward in the era of personalised medicine

by Hunter, Francis W, Wouters, Bradly G, Wilson, William R
Published 2016

A Simple but Highly Effective Approach to Evaluate the Prognostic Performance of Gene Expression Signatures

by Starmans, Maud H. W., Fung, Glenn, Steck, Harald, Wouters, Bradly G., Lambin, Philippe
Published 2011

NanoStringNorm: an extensible R package for the pre-processing of NanoString mRNA and miRNA data

by Waggott, Daryl, Chu, Kenneth, Yin, Shaoming, Wouters, Bradly G., Liu, Fei-Fei, Boutros, Paul C.
Published 2012

Stromal Expression of Hypoxia Regulated Proteins Is an Adverse Prognostic Factor in Colorectal Carcinomas

by Cleven, Arjen H. G., van Engeland, Manon, Wouters, Bradly G., de Bruïne, Adriaan P.
Published 2007

Lysine 63-Polyubiquitination Guards against Translesion Synthesis–Induced Mutations

by Chiu, Roland K, Brun, Jan, Ramaekers, Chantal, Theys, Jan, Weng, Lin, Lambin, Philippe, Gray, Douglas A, Wouters, Bradly G
Published 2006

Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response

by Nagelkerke, Anika, Bussink, Johan, Mujcic, Hilda, Wouters, Bradly G, Lehmann, Steffi, Sweep, Fred CGJ, Span, Paul N
Published 2013

RNF8-Independent Lys63 Poly-Ubiquitylation Prevents Genomic Instability in Response to Replication-Associated DNA Damage

by Ramaekers, Chantal H. M. A., van den Beucken, Twan, Bristow, Robert G., Chiu, Roland K., Durocher, Daniel, Wouters, Bradly G.
Published 2014

Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects

by Molavian, Hamid R., Goldman, Aaron, Phipps, Colin J., Kohandel, Mohammad, Wouters, Bradly G., Sengupta, Shiladitya, Sivaloganathan, Sivabal
Published 2016

Two phases of disulfide bond formation have differing requirements for oxygen

by Koritzinsky, Marianne, Levitin, Fiana, van den Beucken, Twan, Rumantir, Ryan A., Harding, Nicholas J., Chu, Kenneth C., Boutros, Paul C., Braakman, Ineke, Wouters, Bradly G.
Published 2013

Post-transcriptional regulation of MRE11 expression in muscle-invasive bladder tumours

by Martin, Rebecca M., Kerr, Martin, Teo, Mark T.W., Jevons, Sarah J., Koritzinsky, Marianne, Wouters, Bradly G., Bhattarai, Selina, Kiltie, Anne E.
Published 2014

Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia

by Adriaens, Michiel E., Prickaerts, Peggy, Chan-Seng-Yue, Michelle, van den Beucken, Twan, Dahlmans, Vivian E. H., Eijssen, Lars M., Beck, Timothy, Wouters, Bradly G., Voncken, Jan Willem, Evelo, Chris T. A.
Published 2016

Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3

by Prickaerts, Peggy, Adriaens, Michiel E., Beucken, Twan van den, Koch, Elizabeth, Dubois, Ludwig, Dahlmans, Vivian E. H., Gits, Caroline, Evelo, Chris T. A., Chan-Seng-Yue, Michelle, Wouters, Bradly G., Voncken, Jan Willem
Published 2016

MATE2 Expression Is Associated with Cancer Cell Response to Metformin

by Chowdhury, Sanjana, Yung, Eric, Pintilie, Melania, Muaddi, Hala, Chaib, Selim, Yeung, ManTek, Fusciello, Manlio, Sykes, Jenna, Pitcher, Bethany, Hagenkort, Anna, McKee, Trevor, Vellanki, Ravi, Chen, Eric, Bristow, Robert G., Wouters, Bradly G., Koritzinsky, Marianne
Published 2016

MK3 Modulation Affects BMI1-Dependent and Independent Cell Cycle Check-Points

by Prickaerts, Peggy, Niessen, Hanneke E. C., Dahlmans, Vivian E. H., Spaapen, Frank, Salvaing, Juliette, Vanhove, Jolien, Geijselaers, Claudia, Bartels, Stefanie J. J., Partouns, Iris, Neumann, Dietbert, Speel, Ernst-Jan, Takihara, Yoshihiro, Wouters, Bradly G., Voncken, Jan Willem
Published 2015

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

by van den Beucken, Twan, Koch, Elizabeth, Chu, Kenneth, Rupaimoole, Rajesha, Prickaerts, Peggy, Adriaens, Michiel, Voncken, Jan Willem, Harris, Adrian L., Buffa, Francesca M., Haider, Syed, Starmans, Maud H.W., Yao, Cindy Q., Ivan, Mircea, Ivan, Cristina, Pecot, Chad V., Boutros, Paul C., Sood, Anil K., Koritzinsky, Marianne, Wouters, Bradly G.
Published 2014

PTP1B regulates non-mitochondrial oxygen consumption via RNF213 to promote tumour survival during hypoxia

by Banh, Robert S., Iorio, Caterina, Marcotte, Richard, Xu, Yang, Cojocari, Dan, Rahman, Anas Abdel, Pawling, Judy, Zhang, Wei, Sinha, Ankit, Rose, Christopher M., Isasa, Marta, Zhang, Shuang, Wu, Ronald, Virtanen, Carl, Hitomi, Toshiaki, Habu, Toshiyuki, Sidhu, Sachdev S., Koizumi, Akio, Wilkins, Sarah E., Kislinger, Thomas, Gygi, Steven P., Schofield, Christopher J., Dennis, James W., Wouters, Bradly G., Neel, Benjamin G.
Published 2016

Hypoxia Mediated Downregulation of miRNA Biogenesis Promotes Tumor Progression

by Rupaimoole, Rajesha, Wu, Sherry Y., Pradeep, Sunila, Ivan, Cristina, Pecot, Chad V., Gharpure, Kshipra M., Nagaraja, Archana S., Armaiz-Pena, Guillermo N., McGuire, Michael, Zand, Behrouz, Dalton, Heather J., Filant, Justyna, Miller, Justin Bottsford, Lu, Chunhua, Sadaoui, Nouara C., Mangala, Lingegowda S., Taylor, Morgan, van den Beucken, Twan, Koch, Elizabeth, Rodriguez-Aguayo, Cristian, Huang, Li, Bar-Eli, Menashe, Wouters, Bradly G., Radovich, Milan, Ivan, Mircea, Calin, George A, Zhang, Wei, Lopez-Berestein, Gabriel, Sood, Anil K.
Published 2014

Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours

by Galon, Jérôme, Mlecnik, Bernhard, Bindea, Gabriela, Angell, Helen K, Berger, Anne, Lagorce, Christine, Lugli, Alessandro, Zlobec, Inti, Hartmann, Arndt, Bifulco, Carlo, Nagtegaal, Iris D, Palmqvist, Richard, Masucci, Giuseppe V, Botti, Gerardo, Tatangelo, Fabiana, Delrio, Paolo, Maio, Michele, Laghi, Luigi, Grizzi, Fabio, Asslaber, Martin, D'Arrigo, Corrado, Vidal-Vanaclocha, Fernando, Zavadova, Eva, Chouchane, Lotfi, Ohashi, Pamela S, Hafezi-Bakhtiari, Sara, Wouters, Bradly G, Roehrl, Michael, Nguyen, Linh, Kawakami, Yutaka, Hazama, Shoichi, Okuno, Kiyotaka, Ogino, Shuji, Gibbs, Peter, Waring, Paul, Sato, Noriyuki, Torigoe, Toshihiko, Itoh, Kyogo, Patel, Prabhu S, Shukla, Shilin N, Wang, Yili, Kopetz, Scott, Sinicrope, Frank A, Scripcariu, Viorel, Ascierto, Paolo A, Marincola, Francesco M, Fox, Bernard A, Pagès, Franck
Published 2014

Cancer classification using the Immunoscore: a worldwide task force

by Galon, Jérôme, Pagès, Franck, Marincola, Francesco M, Angell, Helen K, Thurin, Magdalena, Lugli, Alessandro, Zlobec, Inti, Berger, Anne, Bifulco, Carlo, Botti, Gerardo, Tatangelo, Fabiana, Britten, Cedrik M, Kreiter, Sebastian, Chouchane, Lotfi, Delrio, Paolo, Arndt, Hartmann, Asslaber, Martin, Maio, Michele, Masucci, Giuseppe V, Mihm, Martin, Vidal-Vanaclocha, Fernando, Allison, James P, Gnjatic, Sacha, Hakansson, Leif, Huber, Christoph, Singh-Jasuja, Harpreet, Ottensmeier, Christian, Zwierzina, Heinz, Laghi, Luigi, Grizzi, Fabio, Ohashi, Pamela S, Shaw, Patricia A, Clarke, Blaise A, Wouters, Bradly G, Kawakami, Yutaka, Hazama, Shoichi, Okuno, Kiyotaka, Wang, Ena, O'Donnell-Tormey, Jill, Lagorce, Christine, Pawelec, Graham, Nishimura, Michael I, Hawkins, Robert, Lapointe, Réjean, Lundqvist, Andreas, Khleif, Samir N, Ogino, Shuji, Gibbs, Peter, Waring, Paul, Sato, Noriyuki, Torigoe, Toshihiko, Itoh, Kyogo, Patel, Prabhu S, Shukla, Shilin N, Palmqvist, Richard, Nagtegaal, Iris D, Wang, Yili, D'Arrigo, Corrado, Kopetz, Scott, Sinicrope, Frank A, Trinchieri, Giorgio, Gajewski, Thomas F, Ascierto, Paolo A, Fox, Bernard A
Published 2012