Two phases of disulfide bond formation have differing requirements for oxygen

Disulfide bonds introduced during or shortly after protein synthesis can occur without oxygen, whereas those introduced during post-translational folding or isomerization are oxygen dependent.

Bibliographic Details
Main Authors: Koritzinsky, Marianne, Levitin, Fiana, van den Beucken, Twan, Rumantir, Ryan A., Harding, Nicholas J., Chu, Kenneth C., Boutros, Paul C., Braakman, Ineke, Wouters, Bradly G.
Format: Online
Language:English
Published: The Rockefeller University Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840938/