Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS)

by Burke, John E., Williams, Roger L.
Published 2013

Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases

by Hon, Wai-Ching, Berndt, Alex, Williams, Roger L.
Published 2011

Allosteric activation of PI3Kα by oncogenic mutations

by Burke, John E., Perisic, Olga, Williams, Roger L.
Published 2013

Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α

by Burke, John E., Vadas, Oscar, Berndt, Alex, Finegan, Tara, Perisic, Olga, Williams, Roger L.
Published 2011

Structural role of Sfi1p–centrin filaments in budding yeast spindle pole body duplication

by Li, Sam, Sandercock, Alan M., Conduit, Paul, Robinson, Carol V., Williams, Roger L., Kilmartin, John V.
Published 2006

PI3Kβ downstream of GPCRs – crucial partners in oncogenesis

by Dbouk, Hashem A., Vadas, Oscar, Williams, Roger L., Backer, Jonathan M.
Published 2012

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity

by Masson, Glenn R., Perisic, Olga, Burke, John E., Williams, Roger L.
Published 2016

Tor forms a dimer through an N-terminal helical solenoid with a complex topology

by Baretić, Domagoj, Berndt, Alex, Ohashi, Yohei, Johnson, Christopher M., Williams, Roger L.
Published 2016

Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi

by Galindo, Antonio, Soler, Nicolas, McLaughlin, Stephen H., Yu, Minmin, Williams, Roger L., Munro, Sean
Published 2016

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

by Zhang, Xuxiao, Vadas, Oscar, Perisic, Olga, Anderson, Karen E., Clark, Jonathan, Hawkins, Phillip T., Stephens, Len R., Williams, Roger L.
Published 2011

Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α☆

by Ganesh, Karuna, van Maldegem, Febe, Telerman, Stephanie B., Simpson, Paul, Johnson, Christopher M., Williams, Roger L., Neuberger, Michael S., Rada, Cristina
Published 2014

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

by Clarke, Jonathan H., Giudici, Maria-Luisa, Burke, John E., Williams, Roger L., Maloney, David J., Marugan, Juan, Irvine, Robin F.
Published 2015

PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control

by Walser, Romy, Burke, John E., Gogvadze, Elena, Bohnacker, Thomas, Zhang, Xuxiao, Hess, Daniel, Küenzi, Peter, Leitges, Michael, Hirsch, Emilio, Williams, Roger L., Laffargue, Muriel, Wymann, Matthias P.
Published 2013

Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11

by Fowler, Melissa L., McPhail, Jacob A., Jenkins, Meredith L., Masson, Glenn R., Rutaganira, Florentine U., Shokat, Kevan M., Williams, Roger L., Burke, John E.
Published 2016

The UBAP1 Subunit of ESCRT-I Interacts with Ubiquitin via a SOUBA Domain

by Agromayor, Monica, Soler, Nicolas, Caballe, Anna, Kueck, Tonya, Freund, Stefan M., Allen, Mark D., Bycroft, Mark, Perisic, Olga, Ye, Yu, McDonald, Bethan, Scheel, Hartmut, Hofmann, Kay, Neil, Stuart J.D., Martin-Serrano, Juan, Williams, Roger L.
Published 2012

Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex

by Ohashi, Yohei, Soler, Nicolas, García Ortegón, Miguel, Zhang, Lufei, Kirsten, Marie L., Perisic, Olga, Masson, Glenn R., Burke, John E., Jakobi, Arjen J., Apostolakis, Apostolos A., Johnson, Christopher M., Ohashi, Maki, Ktistakis, Nicholas T., Sachse, Carsten, Williams, Roger L.
Published 2016

PTEN regulates cilia through Dishevelled

by Shnitsar, Iryna, Bashkurov, Mikhail, Masson, Glenn R., Ogunjimi, Abiodun A., Mosessian, Sherly, Cabeza, Eduardo Aguiar, Hirsch, Calley L., Trcka, Daniel, Gish, Gerald, Jiao, Jing, Wu, Hong, Winklbauer, Rudolf, Williams, Roger L., Pelletier, Laurence, Wrana, Jeffrey L., Barrios-Rodiles, Miriam
Published 2015