Mutagenesis by AID: Being in the Right Place at the Right Time

by Rada, Cristina
Published 2015

Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase η for A/T

by Neuberger, Michael S., Rada, Cristina
Published 2007

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2 −/− ung −/− mice

by Xue, Kanmin, Rada, Cristina, Neuberger, Michael S.
Published 2006

REG-γ associates with and modulates the abundance of nuclear activation-induced deaminase

by Uchimura, Yasuhiro, Barton, Lance F., Rada, Cristina, Neuberger, Michael S.
Published 2011

Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung−/−Msh2−/− mice...

by Kemmerich, Kristin, Dingler, Felix A., Rada, Cristina, Neuberger, Michael S.
Published 2012

AID up-mutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity

by Wang, Meng, Yang, Zizhen, Rada, Cristina, Neuberger, Michael S.
Published 2009

Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes

by Taylor, Benjamin JM, Wu, Yee Ling, Rada, Cristina
Published 2014

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation

by Dingler, Felix A., Kemmerich, Kristin, Neuberger, Michael S., Rada, Cristina
Published 2014

CTNNBL1 Is a Novel Nuclear Localization Sequence-binding Protein That Recognizes RNA-splicing Factors CDC5L and Prp31

by Ganesh, Karuna, Adam, Salome, Taylor, Benjamin, Simpson, Paul, Rada, Cristina, Neuberger, Michael
Published 2011

The dependence of Ig class-switching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin

by Ellyard, Julia I, Benk, Amelie S, Taylor, Benjamin, Rada, Cristina, Neuberger, Michael S
Published 2011

Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice

by Chandra, Anita, van Maldegem, Febe, Andrews, Simon, Neuberger, Michael S., Rada, Cristina
Published 2013

Active demethylation in mouse zygotes involves cytosine deamination and base excision repair

by Santos, Fátima, Peat, Julian, Burgess, Heather, Rada, Cristina, Reik, Wolf, Dean, Wendy
Published 2013

CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex

by van Maldegem, Febe, Maslen, Sarah, Johnson, Christopher M., Chandra, Anita, Ganesh, Karuna, Skehel, Mark, Rada, Cristina
Published 2015

Directed evolution of human scFvs in DT40 cells

by Lim, Alfred W.Y., Williams, Gareth T., Rada, Cristina, Sale, Julian E.
Published 2016

Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α☆

by Ganesh, Karuna, van Maldegem, Febe, Telerman, Stephanie B., Simpson, Paul, Johnson, Christopher M., Williams, Roger L., Neuberger, Michael S., Rada, Cristina
Published 2014

ATMIN Is Required for Maintenance of Genomic Stability and Suppression of B Cell Lymphoma

by Loizou, Joanna I., Sancho, Rocio, Kanu, Nnennaya, Bolland, Daniel J., Yang, Fengtang, Rada, Cristina, Corcoran, Anne E., Behrens, Axel
Published 2011

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

by Taylor, Benjamin JM, Nik-Zainal, Serena, Wu, Yee Ling, Stebbings, Lucy A, Raine, Keiran, Campbell, Peter J, Rada, Cristina, Stratton, Michael R, Neuberger, Michael S
Published 2013

The topography of mutational processes in breast cancer genomes

by Morganella, Sandro, Alexandrov, Ludmil B., Glodzik, Dominik, Zou, Xueqing, Davies, Helen, Staaf, Johan, Sieuwerts, Anieta M., Brinkman, Arie B., Martin, Sancha, Ramakrishna, Manasa, Butler, Adam, Kim, Hyung-Yong, Borg, Åke, Sotiriou, Christos, Futreal, P. Andrew, Campbell, Peter J., Span, Paul N., Van Laere, Steven, Lakhani, Sunil R., Eyfjord, Jorunn E., Thompson, Alastair M., Stunnenberg, Hendrik G., van de Vijver, Marc J., Martens, John W. M., Børresen-Dale, Anne-Lise, Richardson, Andrea L., Kong, Gu, Thomas, Gilles, Sale, Julian, Rada, Cristina, Stratton, Michael R., Birney, Ewan, Nik-Zainal, Serena
Published 2016