How Useful Are Monogenic Rodent Models for the Study of Human Non-Alcoholic Fatty Liver Disease?

by Mann, Jake P., Semple, Robert K., Armstrong, Matthew J.
Published 2016

Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin production

by Groeneveld, Matthijs P., Brierley, Gemma V., Rocha, Nuno M., Siddle, Kenneth, Semple, Robert K.
Published 2016

Successful Treatment of Type B Insulin Resistance With Rituximab

by Manikas, Emmanouil-Dimitrios, Isaac, Iona, Semple, Robert K., Malek, Rana, Führer, Dagmar, Moeller, Lars C.
Published 2015

Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes

by Eiden, Michael, Koulman, Albert, Hatunic, Mensud, West, James A., Murfitt, Steven, Osei, Michael, Adams, Claire, Wang, Xinzhu, Chu, Yajing, Marney, Luke, Roberts, Lee D., O’Rahilly, Stephen, Semple, Robert K., Savage, David B., Griffin, Julian L.
Published 2015

Early Diagnosis of Werner's Syndrome Using Exome-Wide Sequencing in a Single, Atypical Patient

by Raffan, Eleanor, Hurst, Liam A., Turki, Saeed Al, Carpenter, Gillian, Scott, Carol, Daly, Allan, Coffey, Alison, Bhaskar, Sanjeev, Howard, Eleanor, Khan, Naz, Kingston, Helen, Palotie, Aarno, Savage, David B., O'Driscoll, Mark, Smith, Claire, O'Rahilly, Stephen, Barroso, Inês, Semple, Robert K.
Published 2011

Serotonin 2C Receptor Agonists Improve Type 2 Diabetes via Melanocortin-4 Receptor Signaling Pathways

by Zhou, Ligang, Sutton, Gregory M., Rochford, Justin J., Semple, Robert K., Lam, Daniel D., Oksanen, Laura J., Thornton-Jones, Zoe D., Clifton, Peter G., Yueh, Chen-Yu, Evans, Mark L., McCrimmon, Rory J., Elmquist, Joel K., Butler, Andrew A., Heisler, Lora K.
Published 2007

An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy

by Weedon, Michael N., Ellard, Sian, Prindle, Marc J., Caswell, Richard, Allen, Hana Lango, Oram, Richard, Godbole, Koumudi, Yajnik, Chittaranjan S., Sbraccia, Paolo, Novelli, Giuseppe, Turnpenny, Peter, McCann, Emma, Goh, Kim Jee, Wang, Yukai, Fulford, Jonathan, McCulloch, Laura J., Savage, David B., O’Rahilly, Stephen, Kos, Katarina, Loeb, Lawrence A., Semple, Robert K., Hattersley, Andrew T.
Published 2013

Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations

by Huang-Doran, Isabel, Tomlinson, Patsy, Payne, Felicity, Gast, Alexandra, Sleigh, Alison, Bottomley, William, Harris, Julie, Daly, Allan, Rocha, Nuno, Rudge, Simon, Clark, Jonathan, Kwok, Albert, Romeo, Stefano, McCann, Emma, Müksch, Barbara, Dattani, Mehul, Zucchini, Stefano, Wakelam, Michael, Foukas, Lazaros C., Savage, David B., Murphy, Rinki, O’Rahilly, Stephen, Barroso, Inês, Semple, Robert K.
Published 2016

Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis

by Nead, Kevin T., Sharp, Stephen J., Thompson, Deborah J., Painter, Jodie N., Savage, David B., Semple, Robert K., Barker, Adam, Perry, John R. B., Attia, John, Dunning, Alison M., Easton, Douglas F., Holliday, Elizabeth, Lotta, Luca A., O’Mara, Tracy, McEvoy, Mark, Pharoah, Paul D. P., Scott, Rodney J., Spurdle, Amanda B., Langenberg, Claudia, Wareham, Nicholas J., Scott, Robert A.
Published 2015

Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes

by Yaghootkar, Hanieh, Scott, Robert A., White, Charles C., Zhang, Weihua, Speliotes, Elizabeth, Munroe, Patricia B., Ehret, Georg B., Bis, Joshua C., Fox, Caroline S., Walker, Mark, Borecki, Ingrid B., Knowles, Joshua W., Yerges-Armstrong, Laura, Ohlsson, Claes, Perry, John R.B., Chambers, John C., Kooner, Jaspal S., Franceschini, Nora, Langenberg, Claudia, Hivert, Marie-France, Dastani, Zari, Richards, J. Brent, Semple, Robert K., Frayling, Timothy M.
Published 2014

Insulin Receptor and the Kidney: Nephrocalcinosis in Patients with Recessive INSR Mutations

by Simpkin, Arabella, Cochran, Elaine, Cameron, Fergus, Dattani, Mehul, de Bock, Martin, Dunger, David B., Forsander, Gun, Guran, Tulay, Harris, Julie, Isaac, Iona, Hussain, Khalid, Kleta, Robert, Peters, Catherine, Tasic, Velibor, Williams, Rachel, Yap Kok Peng, Fabian, O'Rahilly, Stephan, Gorden, Philipp, Semple, Robert K., Bockenhauer, Detlef
Published 2014

Clinical Delineation and Natural History of the PIK3CA-Related Overgrowth Spectrum**

by Keppler-Noreuil, Kim M, Sapp, Julie C, Lindhurst, Marjorie J, Parker, Victoria ER, Blumhorst, Cathy, Darling, Thomas, Tosi, Laura L, Huson, Susan M, Whitehouse, Richard W, Jakkula, Eveliina, Grant, Ian, Balasubramanian, Meena, Chandler, Kate E, Fraser, Jamie L, Gucev, Zoran, Crow, Yanick J, Brennan, Leslie Manace, Clark, Robin, Sellars, Elizabeth A, Pena, Loren DM, Krishnamurty, Vidya, Shuen, Andrew, Braverman, Nancy, Cunningham, Michael L, Sutton, V Reid, Tasic, Velibor, Graham, John M, Geer, Joseph, Henderson, Alex, Semple, Robert K, Biesecker, Leslie G
Published 2014

Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes

by Yaghootkar, Hanieh, Lamina, Claudia, Scott, Robert A., Dastani, Zari, Hivert, Marie-France, Warren, Liling L., Stancáková, Alena, Buxbaum, Sarah G., Lyytikäinen, Leo-Pekka, Henneman, Peter, Wu, Ying, Cheung, Chloe Y.Y., Pankow, James S., Jackson, Anne U., Gustafsson, Stefan, Zhao, Jing Hua, Ballantyne, Christie M., Xie, Weijia, Bergman, Richard N., Boehnke, Michael, el Bouazzaoui, Fatiha, Collins, Francis S., Dunn, Sandra H., Dupuis, Josee, Forouhi, Nita G., Gillson, Christopher, Hattersley, Andrew T., Hong, Jaeyoung, Kähönen, Mika, Kuusisto, Johanna, Kedenko, Lyudmyla, Kronenberg, Florian, Doria, Alessandro, Assimes, Themistocles L., Ferrannini, Ele, Hansen, Torben, Hao, Ke, Häring, Hans, Knowles, Joshua W., Lindgren, Cecilia M., Nolan, John J., Paananen, Jussi, Pedersen, Oluf, Quertermous, Thomas, Smith, Ulf, Lehtimäki, Terho, Liu, Ching-Ti, Loos, Ruth J.F., McCarthy, Mark I., Morris, Andrew D., Vasan, Ramachandran S., Spector, Tim D., Teslovich, Tanya M., Tuomilehto, Jaakko, van Dijk, Ko Willems, Viikari, Jorma S., Zhu, Na, Langenberg, Claudia, Ingelsson, Erik, Semple, Robert K., Sinaiko, Alan R., Palmer, Colin N.A., Walker, Mark, Lam, Karen S.L., Paulweber, Bernhard, Mohlke, Karen L., van Duijn, Cornelia, Raitakari, Olli T., Bidulescu, Aurelian, Wareham, Nick J., Laakso, Markku, Waterworth, Dawn M., Lawlor, Debbie A., Meigs, James B., Richards, J. Brent, Frayling, Timothy M.
Published 2013