Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes

Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes

The mechanisms that predispose to hypertension, coronary artery disease (CAD), and type 2 diabetes (T2D) in individuals of normal weight are poorly understood. In contrast, in monogenic primary lipodystrophy—a reduction in subcutaneous adipose tissue—it is clear that it is adipose dysfunction that c...

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Bibliographic Details
Main Authors: Yaghootkar, Hanieh, Scott, Robert A., White, Charles C., Zhang, Weihua, Speliotes, Elizabeth, Munroe, Patricia B., Ehret, Georg B., Bis, Joshua C., Fox, Caroline S., Walker, Mark, Borecki, Ingrid B., Knowles, Joshua W., Yerges-Armstrong, Laura, Ohlsson, Claes, Perry, John R.B., Chambers, John C., Kooner, Jaspal S., Franceschini, Nora, Langenberg, Claudia, Hivert, Marie-France, Dastani, Zari, Richards, J. Brent, Semple, Robert K., Frayling, Timothy M.
Format: Online
Language:English
Published: American Diabetes Association 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392920/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392920/

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