The Role of Mitochondrial DNA Mutations in Mammalian Aging

by Kujoth, Gregory C, Bradshaw, Patrick C, Haroon, Suraiya, Prolla, Tomas A
Published 2007

Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program

by Edwards, Michael G, Anderson, Rozalyn M, Yuan, Ming, Kendziorski, Christina M, Weindruch, Richard, Prolla, Tomas A
Published 2007

Long-Term Bezafibrate Treatment Improves Skin and Spleen Phenotypes of the mtDNA Mutator Mouse

by Dillon, Lloye M., Hida, Aline, Garcia, Sofia, Prolla, Tomas A., Moraes, Carlos T.
Published 2012

Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer’s disease

by Kukreja, Lokesh, Kujoth, Gregory C, Prolla, Tomas A, Van Leuven, Fred, Vassar, Robert
Published 2014

Gene expression profiling reveals differential effects of sodium selenite, selenomethionine, and yeast-derived selenium in the mouse

by Barger, Jamie L., Kayo, Tsuyoshi, Pugh, Thomas D., Vann, James A., Power, Ronan, Dawson, Karl, Weindruch, Richard, Prolla, Tomas A.
Published 2011

Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain

by Taylor, Sean D, Ericson, Nolan G, Burton, Joshua N, Prolla, Tomas A, Silber, John R, Shendure, Jay, Bielas, Jason H
Published 2014

Dysregulation of Mitochondrial Quality Control Processes Contribute to Sarcopenia in a Mouse Model of Premature Aging

by Joseph, Anna-Maria, Adhihetty, Peter J., Wawrzyniak, Nicholas R., Wohlgemuth, Stephanie E., Picca, Anna, Kujoth, Gregory C., Prolla, Tomas A., Leeuwenburgh, Christiaan
Published 2013

Transcriptomics and Metabonomics Identify Essential Metabolic Signatures in Calorie Restriction (CR) Regulation across Multiple Mouse Strains

by Collino, Sebastiano, Martin, François-Pierre J., Montoliu, Ivan, Barger, Jamie L., Da Silva, Laeticia, Prolla, Tomas A., Weindruch, Richard, Kochhar, Sunil
Published 2013

Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions

by Fuke, Satoshi, Kametani, Mizue, Yamada, Kazuyuki, Kasahara, Takaoki, Kubota-Sakashita, Mie, Kujoth, Gregory C, Prolla, Tomas A, Hitoshi, Seiji, Kato, Tadafumi
Published 2014

A Conserved Transcriptional Signature of Delayed Aging and Reduced Disease Vulnerability Is Partially Mediated by SIRT3

by Barger, Jamie L., Anderson, Rozalyn M., Newton, Michael A., da Silva, Cristina, Vann, James A., Pugh, Thomas D., Someya, Shinichi, Prolla, Tomas A., Weindruch, Richard
Published 2015

Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice

by Safdar, Adeel, Khrapko, Konstantin, Flynn, James M., Saleem, Ayesha, De Lisio, Michael, Johnston, Adam P. W., Kratysberg, Yevgenya, Samjoo, Imtiaz A., Kitaoka, Yu, Ogborn, Daniel I., Little, Jonathan P., Raha, Sandeep, Parise, Gianni, Akhtar, Mahmood, Hettinga, Bart P., Rowe, Glenn C., Arany, Zoltan, Prolla, Tomas A., Tarnopolsky, Mark A.
Published 2016