A Conserved Transcriptional Signature of Delayed Aging and Reduced Disease Vulnerability Is Partially Mediated by SIRT3

Aging is the most significant risk factor for a range of diseases, including many cancers, neurodegeneration, cardiovascular disease, and diabetes. Caloric restriction (CR) without malnutrition delays aging in diverse species, and therefore offers unique insights into age-related disease vulnerabili...

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Bibliographic Details
Main Authors: Barger, Jamie L., Anderson, Rozalyn M., Newton, Michael A., da Silva, Cristina, Vann, James A., Pugh, Thomas D., Someya, Shinichi, Prolla, Tomas A., Weindruch, Richard
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382298/