Recent insights into the molecular mechanisms of the NLRP3 inflammasome activation

by Próchnicki, Tomasz, Mangan, Matthew S., Latz, Eicke
Published 2016

Mechanisms of Sterile Inflammation

by Rubartelli, Anna, Lotze, Michael T., Latz, Eicke, Manfredi, Angelo
Published 2013

Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage

by Brandstetter, Carolina, Mohr, Lena K. M., Latz, Eicke, Holz, Frank G., Krohne, Tim U.
Published 2015

AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC

by Hornung, Veit, Ablasser, Andrea, Charrel-Dennis, Marie, Bauernfeind, Franz, Horvath, Gabor, Caffrey, Daniel R., Latz, Eicke, Fitzgerald, Katherine A.
Published 2009

Dental Calculus Stimulates Interleukin-1β Secretion by Activating NLRP3 Inflammasome in Human and Mouse Phagocytes

by Montenegro Raudales, Jorge Luis, Yoshimura, Atsutoshi, SM, Ziauddin, Kaneko, Takashi, Ozaki, Yukio, Ukai, Takashi, Miyazaki, Toshihiro, Latz, Eicke, Hara, Yoshitaka
Published 2016

Importance of extra- and intracellular domains of TLR1 and TLR2 in NFκB signaling

by Sandor, Frantisek, Latz, Eicke, Re, Fabio, Mandell, Leisa, Repik, Galina, Golenbock, Douglas T., Espevik, Terje, Kurt-Jones, Evelyn A., Finberg, Robert W.
Published 2003

LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

by Fitzgerald, Katherine A., Rowe, Daniel C., Barnes, Betsy J., Caffrey, Daniel R., Visintin, Alberto, Latz, Eicke, Monks, Brian, Pitha, Paula M., Golenbock, Douglas T.
Published 2003

Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line: A Point Mutation in a Conserved Region of Md-2 Abolishes Endotoxin-Induced Signaling

by Schromm, Andra B., Lien, Egil, Henneke, Philipp, Chow, Jesse C., Yoshimura, Atsutoshi, Heine, Holger, Latz, Eicke, Monks, Brian G., Schwartz, David A., Miyake, Kensuke, Golenbock, Douglas T.
Published 2001

Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease

by McAuley, Julie L., Tate, Michelle D., MacKenzie-Kludas, Charley J., Pinar, Anita, Zeng, Weiguang, Stutz, Andrea, Latz, Eicke, Brown, Lorena E., Mansell, Ashley
Published 2013

Optimization of transcription factor binding map accuracy utilizing knockout-mouse models

by Krebs, Wolfgang, Schmidt, Susanne V., Goren, Alon, De Nardo, Dominic, Labzin, Larisa, Bovier, Anton, Ulas, Thomas, Theis, Heidi, Kraut, Michael, Latz, Eicke, Beyer, Marc, Schultze, Joachim L.
Published 2014

CD36 coordinates NLRP3 inflammasome activation by facilitating the intracellular nucleation from soluble to particulate ligands in sterile inflammation

by Sheedy, Frederick J., Grebe, Alena, Rayner, Katey J., Kalantari, Parisa, Ramkhelawon, Bhama, Carpenter, Susan B., Becker, Christine E., Ediriweera, Hasini N., Mullick, Adam E., Golenbock, Douglas T., Stuart, Lynda M., Latz, Eicke, Fitzgerald, Katherine A., Moore, Kathryn J.
Published 2013

NLRP3 is activated in Alzheimer´s disease and contributes to pathology in APP/PS1 mice

by Heneka, Michael T., Kummer, Markus P., Stutz, Andrea, Delekate, Andrea, Schwartz, Stephanie, Saecker, Ana, Griep, Angelika, Axt, Daisy, Remus, Anita, Tzeng, Te-Chen, Gelpi, Ellen, Halle, Annett, Korte, Martin, Latz, Eicke, Golenbock, Douglas
Published 2012

Distinct surveillance pathway for immunopathology during acute infection via autophagy and SR-BI

by Pfeiler, Susanne, Khandagale, Avinash B., Magenau, Astrid, Nichols, Maryana, Heijnen, Harry F. G., Rinninger, Franz, Ziegler, Tilman, Seveau, Stephanie, Schubert, Sören, Zahler, Stefan, Verschoor, Admar, Latz, Eicke, Massberg, Steffen, Gaus, Katharina, Engelmann, Bernd
Published 2016

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

by Tate, Michelle D., Ong, James D. H., Dowling, Jennifer K., McAuley, Julie L., Robertson, Avril B., Latz, Eicke, Drummond, Grant R., Cooper, Matthew A., Hertzog, Paul J., Mansell, Ashley
Published 2016

Weekly Treatment of 2-Hydroxypropyl-β-cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice

by Walenbergh, Sofie M. A., Houben, Tom, Hendrikx, Tim, Jeurissen, Mike L. J., van Gorp, Patrick J., Vaes, Nathalie, Olde Damink, Steven W. M., Verheyen, Fons, Koek, Ger H., Lütjohann, Dieter, Grebe, Alena, Latz, Eicke, Shiri-Sverdlov, Ronit
Published 2015

Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors

by Sarvestani, Soroush T., Stunden, H. James, Behlke, Mark A., Forster, Samuel C., McCoy, Claire E., Tate, Michelle D., Ferrand, Jonathan, Lennox, Kim A., Latz, Eicke, Williams, Bryan R.G., Gantier, Michael P.
Published 2015

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

by Xue, Jia, Schmidt, Susanne V., Sander, Jil, Draffehn, Astrid, Krebs, Wolfgang, Quester, Inga, De Nardo, Dominic, Gohel, Trupti D., Emde, Martina, Schmidleithner, Lisa, Ganesan, Hariharasudan, Nino-Castro, Andrea, Mallmann, Michael R., Labzin, Larisa, Theis, Heidi, Kraut, Michael, Beyer, Marc, Latz, Eicke, Freeman, Tom C., Ulas, Thomas, Schultze, Joachim L.
Published 2014

High density lipoprotein mediates anti-inflammatory transcriptional reprogramming of macrophages via the transcriptional repressor ATF3

by De Nardo, Dominic, Labzin, Larisa I., Kono, Hajime, Seki, Reiko, Schmidt, Susanne V., Beyer, Marc, Xu, Dakang, Zimmer, Sebastian, Lahrmann, Catharina, Schildberg, Frank A., Vogelhuber, Johanna, Kraut, Michael, Ulas, Thomas, Kerksiek, Anja, Krebs, Wolfgang, Bode, Niklas, Grebe, Alena, Fitzgerald, Michael L., Hernandez, Nicholas J., Williams, Bryan, Knolle, Percy, Kneilling, Manfred, Röcken, Martin, Lütjohann, Dieter, Wright, Samuel D., Schultze, Joachim L., Latz, Eicke
Published 2013

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA

by Sirois, Cherilyn M., Jin, Tengchuan, Miller, Allison L., Bertheloot, Damien, Nakamura, Hirotaka, Horvath, Gabor L., Mian, Abubakar, Jiang, Jiansheng, Schrum, Jacob, Bossaller, Lukas, Pelka, Karin, Garbi, Natalio, Brewah, Yambasu, Tian, Jane, Chang, ChewShun, Chowdhury, Partha S., Sims, Gary P., Kolbeck, Roland, Coyle, Anthony J., Humbles, Alison A., Xiao, T. Sam, Latz, Eicke
Published 2013

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA

by Sirois, Cherilyn M., Jin, Tengchuan, Miller, Allison L., Bertheloot, Damien, Nakamura, Hirotaka, Horvath, Gabor L., Mian, Abubakar, Jiang, Jiansheng, Schrum, Jacob, Bossaller, Lukas, Pelka, Karin, Garbi, Natalio, Brewah, Yambasu, Tian, Jane, Chang, ChewShun, Chowdhury, Partha S., Sims, Gary P., Kolbeck, Roland, Coyle, Anthony J., Humbles, Alison A., Xiao, T. Sam, Latz, Eicke
Published 2014